Winniecia Dkhar
Manipal Academy of Higher Education, India
Title: Evaluation of the effect of breast density in breast tumor conspicuity in Diffussion Weighted MRI
Biography
Biography: Winniecia Dkhar
Abstract
Introduction and Aim: A sensitive and acceptable screening regimen for breast cancer is essential. Magnetic resonance imaging (MRI) of the breast is highly sensitive for the diagnosis of breast lesions irrespective of the breast density. MR imaging of the breast is increasingly used as an adjunct to mammography and ultrasonography to improve the detection and characterization of primary and recurrent breast cancers and for evaluation of the response to therapy. DWI sequence derives quantitative and qualitative data reflecting changes at the cellular level and information on the tumor cellularity. DWI heighten the sensitivity and thereby improve diagnostic accuracy. The purpose of this study was to find out the effect of breast density on breast tumor conspicuity detected in Diffusion Weighted MRI. Bilateral MRI breast scan was conducted with DWI pulse sequences.
Method: Bilateral MRI breast scan was conducted with DWI pulse sequences. For quantitative analysis, ROIs was drawn manually in the tissues and the average ADC will be acquired for quantitatively evaluating the differential diagnosis. The breast density was categorized according to ACR, under the category A, B, C, D. Quantify the tumor conspicuity on ADC maps, the contrast to noise ratio (CNR) was calculated for each lesion detection.
Result and Conclusion: The ADC cut off values were found to be higher for benign lesions than malignant lesions and DWI increases the lesion conspicuity without altering the detection rate. While benign lesions exhibited a CNR that was higher than malignant lesions. DWI sequences have a promising application in diagnosing of breast lesions especially in the dense breast which is often missed in mammography and in women at high genetic risk for breast cancer.